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The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

Currently, the first randomized, double-blind phase III trial is underway to evaluate the effects of oral Semaglutide in AD prevention and progression

Pancreatitis One of the more severe, though less common, side effects of GLP-1 drugs is pancreatitis

N Engl J Med 2016;375:311322

[4] [5] Most patients taking GLP-1 receptor agonists will not experience ocular complications, though rare reports of other eye conditions exist with uncertain causality

Aetna typically requires evidence that patients can tolerate the medication before approving long-term coverage