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However, speed matters

This can lead to a lingering feeling of queasiness or a heavy sensation in the upper abdomen

Because it reduces appetite and makes you feel satisfied after meals, semaglutide can lead to significant weight loss when combined with a healthy diet and regular physical activity

Fat contributed 70% to weight loss, lean body mass 30%

GLP-1Rs exhibit broad tissue distribution, spanning the pancreas, gastrointestinal tract, cardiovascular system, and central nervous system, allowing GLP-1 RAs to impact multiple organ systems 2,3
Epigenetic effects include changes to histone methylation status at genes governing fat cell differentiation
