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What the clinical trials actually show The SURMOUNT-1 trial remains the landmark study for tirzepatide and weight loss

For maximum weight loss or glycemic control, tirzepatide is the clear choice

Participants who do not tolerate at least 10 mg by Visit 12 (Week 48) will not be eligible for randomization and will be discontinued from the study and from the study drug

Even trace amounts of metal ions from the rubber stopper or glass vial can catalyze oxidation reactions over time

Focus on tolerance

Clinicians should equip patients with clear, written instructions on what symptoms to watch for and how to quickly reach their care team if needed