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The SELECT trial tested semaglutide 2.4 mg in over 17,000 people with cardiovascular disease and obesity over an average of 3.3 years

The current evidence supports continued GLP-1 therapy for sustained weight management and metabolic benefits, with effectiveness maintained through combined pharmacological and lifestyle approaches rather than the medication losing its pharmacological action over time

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[DOI] [PubMed] [Google Scholar] Lim GE, Brubaker PL

Consistency during this period is key

The filtration process allows for the proper nutrients to be absorbed and the rest of the toxic substances to be flushed out of our systems