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Mitochondrial effects include ETCcomplex rebalancing, ATP/ADP flux modulation, ROSthreshold displacement, mitochondrialmembrane potential polarity shifts and ERmitochondria bidirectional stresssignal integration
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eClinicalMedicine 75 , 102782 (2024)
In Phase 2 clinical trials, gastrointestinal side effects like nausea (28% of patients) and diarrhea (24%) peaked at weeks 6-8, then substantially resolved by week 12
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By prioritizing patient education and improving counseling for patients and prescribers on dose titration, product switching, and management of expected gastrointestinal effects, alongside clear prescribing guidance and poison center recommendations, the healthcare community can help ensure that the benefits of GLP-1 RAs are maximized while minimizing adverse outcomes
