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The drugs work by mimicking GLP-1, a hormone the gut releases after eating that stimulates insulin release and suppresses glucagon to control blood sugar
10.2337/diab.43.4.535
The bigger lesson is simple: obesity treatment is chronic care
GLP-1 receptor agonists slow gastric emptying and reduce appetite, which may decrease overall nutrient intake in some individuals
GLP-1R also functions as a pleiotropic GPCR that can activate distinct signaling cascades depending on ligand bias and the local cellular environment [511]
