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As with all GLP-1 class medications, retatrutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome, and is not appropriate for patients with a history of pancreatitis

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Those suffering from type 1 Diabetes

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Avoid high-fat and processed foods

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Its three targets are distinct G-protein-coupled receptors: GLP-1 receptor activity is associated with incretin-mediated insulin signalling and central appetite pathways

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The study was registered in the EU Clinical Trials Register (EudraCT 2019-000781-38)

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