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Chen H, Zhang SM, Hernan MA, Schwarzschild MA, Willett WC, Colditz GA, et al

But that doesnt have to mean living off salads and rice cakes

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IR is associated with chronic low-grade inflammation, hypothalamicpituitaryadrenal (HPA) axis dysregulation, impaired neuroplasticity, mitochondrial dysfunction, and altered reward processing mechanisms that may contribute to core depressive features such as anhedonia, cognitive slowing, and emotional dysregulation
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