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These findings indicated that TGF-1 + IL-1 was sufficient to induce fibroblast activation by activating NLRP3 inflammasome, but insufficient to cause NLRP3/caspase-1/GSDMD-mediated fibroblast pyroptosis, while the underlying mechanism remains to be further explored

Furthermore, the number of neuron-derived orphan receptor 1 (NOR1) which can modulate VSMC proliferation, is decreased by GLP-1RAs in a dose-dependent manner in mice [121]

Rosenstock, J., Reusch, J., Bush, M., Yang, F., Stewart, M

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doi: 10.1016/j.tips.2012.03.014