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Yanai, H., Adachi, H., Hamasaki, H., Masui, Y., et

In the N171-82Q transgenic mouse model, exendin-4 treatment improved motor function, prolonged survival, and reduced mutant huntingtin aggregation in the brain

Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes

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Besides directly inhibiting IRS-1, the underlying mechanism of insulin resistance by inflammatory mediators occurs through the activation of NF-B, and inhibitor of nuclear factor kappa B kinase subunit (IKK) [22,35,36,39]

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