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There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis.

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The incretin hormone glucagon-like peptide 1 (GLP-1) has been implicated in the gutrenal axis and incretin-based therapies might reduce the burden of diabetic kidney disease

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Van DerSchootA, Drysdale C, Whelan K,DimidiE. The effect offibersupplementation on chronic constipation in adults: An updated systematic review and meta-analysis of randomized controlled trials.AmJ ClinNutr.2022;116:953-969. doi:10.1093/ajcn/nqac184

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These medications also delay gastric emptying through neural mechanisms, increasing the risk for perioperative aspiration during anaesthesia and sedation

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Patient-specific compounded oral GLP-1s through licensed pharmacies are a separate lawful category

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