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Metformin, a first-line therapy, enhances insulin sensitivity by activating AMP-activated protein kinase (AMPK), reducing hepatic gluconeogenesis, and mitigating oxidative stress [8,9,10,11,12]

67.The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: the SURPASS clinical trials

This precision approach aligns with the goal of long-term treatment adherence and sustained metabolic benefit

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As we discussed, estrogen enhances GLP-1 receptor sensitivity

Ozempic is a member of a new class of medication known as GLP-1 receptor agonists, and its sugar-reducing effect is due to a more direct impact on insulin secretion and slowed gastric emptying, resulting in the GLP-1 medications added bonus of weight loss