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Ludvik B, et al

A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm

Adjustments to lifestyle, such as incorporating regular physical activity and adopting dietary modifications, might enhance the overall effectiveness of tirzepatide

(2025) NICE [accessed 15 January 2026]

Semaglutide only affects GLP-1

Since these medications impact insulin resistance and hormone regulation , its essential to: Track ovulation using ovulation predictor kits (OPKs) or basal body temperature