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Significant weight regain was observed in both subgroups (WMD = 1.45 kg, 95% CI 0.62 to 2.28, P = 0.006, I 2 = 72%

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For reduced cholesterol, islets were pre-incubated in 10 M simvastatin (S6196, Sigma Aldrich) diluted in RPMI-1640 supplemented with 10% lipoprotein deficient serum (LPDS) (S5394, Sigma Aldrich) and 1% p/s for a minimum of 18 hours prior to the assays

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These landmark investigations employed rigorous double-blind, placebo-controlled methodology eliminating confounding variables

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