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In Summary it led to : A1c Reduction up to 2% Weight loss reaching 29% Reduced Liver fat Drop blood pressure by 14 points decreased inflammatory markers reduced osteoarthritis flare ups Retatrutide shows significant weight loss in obesity and knee osteoarthritis trial In the Phase 3 TRIUMPH-4 trial (68 weeks), retatrutide demonstrated unprecedented weight loss in adults with obesity and knee osteoarthritis, with participants on the highest dose (12 mg) achieving an average weight loss of 28.7% (approximately 71 lbs)

Greater rates of ceasing the drug on account of side effects

Theres not enough data on whether Wegovy passes into breast milk, so it should be avoided during breastfeeding

This can complicate your mental health treatment and make it difficult to assess whether your antidepressant is working effectively