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Sitagliptin (Januvia), the first in a new class of antihyperglycemic agents, was approved in October 2006

Supporting Data: Studies show that protein-rich meals can increase GLP-1 secretion by 25-40%, depending on the protein type

These drugs are commonly prescribed for weight management, to treat type 2 diabetes, or to reduce the risk of heart attacks and stroke in people with cardiovascular disease

GLP-1s also activate receptors in the hypothalamus area of the brain (the control center for hunger and thirst) to curb appetite

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The receptor's large, complex binding surface, characteristic of class B GPCRs, was thought to require the extensive contact area that only a peptide could provide