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Even though you are moving within the same family of drugs, the shift from a dual agonist (tirzepatide) to a single agonist (semaglutide) can cause temporary symptoms

Scientific References Type 2 diabetes in adults: management (NG28)

Clinical trials have demonstrated that Semaglutide can lead to significant weight loss in individuals who are overweight or obese
Patient safety advice : If you experience any unexpected or troubling symptoms whilst taking Ozempic, including sleep disturbances, discuss them with your healthcare provider

North America dominated the GLP-1 receptor agonist market with a market share of 61.23% in 2025