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According to the UK SmPC (Summary of Product Characteristics), semaglutide does not reduce the effectiveness of combined oral contraceptives, and additional contraception is not routinely required

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Their diabetic control and cardiometabolic risk factors like blood pressure and cholesterol also tend to revert to their previous state. Dr Tan highlights the Surmount-4 clinical trial that looked at the issue of weight regain after treatment with tirzepatide
