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Adult patients with obesity or overweight and weight-related comorbidities who previously completed SURMOUNT-5 were enrolled in the trial a total of 376 participants were enrolled and randomly assigned in a 3:2 ratio to either orforglipron maximum tolerated dose (24 mg or 36 mg) or placebo, as an adjunct to healthy diet and physical activity

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However, they should be used under medical supervision, and discontinued before conception to ensure safety

Even on a mild day, the inside temperature can rise above 86F (30C) in a short time

This is particularly helpful if these symptoms occur alongside physical side effects like nausea or disrupted sleep

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