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It attempts to address the knowledge gaps and give a comprehensive understanding of the treatments long-term effects, resulting in better clinical decisions and patient outcomes

In patients with IIH, abrupt cessation of GLP-1RA therapy has been reported to lead to a return of symptoms or new onset IIH in two separate case reports, highlighting the requirement of continuous therapy (22,24)

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Lastly, while insulin may influence gastric emptying through modulating blood glucose levels, hyperinsulinaemia per se does not appear to affect gastric emptying [58]

In the early pathological state of AD, glucose utilization (up to 45%) is reduced, which is closely related to the alteration of insulin signaling