retatrutide triple agonist glp-1 gip glucagon phase 2 nejm 2023 Research Guide: What the Trial Data Reported (2026) Retatrutide UK: How It Works,

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In the STEP 5 study, participants taking semaglutide lost an average of 15.2% of their body weight over two years, compared with 2.6% in the placebo group

GLP-1 medications work by mimicking the bodys natural GLP-1 hormones that regulate blood sugar, insulin release, digestion, and appetite

Br J Anaesth 118(3):363371

Public Plan Spending Context The Globe and Mail reports that public plans spent $794 million on Ozempic in 2024, and if plans cover Mounjaro, it could cost them an estimated $1.97 billion over three years, about $820 million more than the plans currently spend on comparable drugs over a similar period [Source: theglobeandmail.com/business/economy/article-canada-drug-agency-mounjaro-recommendation-type-2-diabetes/]

in an additional analysis, we adjusted the hazard ratio for calendar year in three year intervals in a multivariable model (in addition to propensity score weighting)