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Semaglutide Insomnia: Why You Feel "Wired" & How to Fix It Share Key Takeaways The Cause: GLP-1 medications may stimulate the Orexin ("alertness") pathway, creating a "wired" sensation

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GLP-1 may also help to reduce food intake and promote weight loss in people who are obese

This work was supported by the National Natural Science Foundation of China (81790640, 32070989, 31872766, 31571075, 82070993, and 31571072), the Ministry of Science and Technology of China (2011CB504602 and 2015AA020512), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), ZJLab, Shanghai Center for Brain Science and Brain-Inspired Technology, and Sanming Project of Medicine in Shenzhen (SZSM202011015)

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