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It is important to note that system Xc- function is regulated by glutamate levels, because glutamate is exchanged for cystine in a 1:1 ratio by system Xc-

Microscopy U-937 cells were cultured in complete RPMI medium

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Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ (2003) Nicotinic acetylcholine receptor 7 subunit is an essential regulator of inflammation

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