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This condition is linked to the presence of an autoantibody targeting folate receptor alpha, the primary transporter of folate from the bloodstream to the brain and from mother to fetus

After 180 min of anaerobic incubation at 37 C, the entire culture volume was collected into 50 mL conical tubes with pipetting and scraping to capture adherent cells, and the cells were centrifuged at 4000 g for 10 min, yielding pellets with a wet weight of ~100 mg

Although these drugs are considered first-line therapies, each presents notable limitations

However, fat stores (i.e., epididymal white adipose tissue) were not significantly depleted in liver-specific Gclc KO mice

Greten, F