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LCR is primarily stored in skeletal muscles and the heart at approximately 95%, while significantly lower concentrations are stored in the plasma 1

Even though the exact etiology remains unknown, genetic factors (polymorphisms), nervous system alterations and autonomic dysregulation, and environmental factors (use and abuse of cannabinoids) are postulated as possible triggers

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Mandra, E.S

Clinicians Brief 2011, 9(3), 73-76

Evidence has summarized the risks associated with LC, indicating that an intake of 2 g or less per day is relatively safe for most people without causing severe side effects, whether long-term or acute