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Keep in mind that the kidneys are responsible for clearing MMA, so kidney disease can cause falsely high serum MMA levels or falsely low uMMA levels

CYP450 Another family of enzymes involved in the metabolism of AA to eicosanoids, but also responsible for the metabolism of sterols, steroids, vitamin A, and vitamin D, are the enzymes from the cytochrome P450 (CYP450) family [131], which are also the most versatile class of enzymes metabolizing xenobiotics, including drugs, both in the liver and extrahepatically, including in the skin [131, 132]

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Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame

Exp Eye Res 28:110110 Finsterer J (2022) Novel SLC25A4 variant causes mitochondrial depletion rather than Kearns-Sayre syndrome

This combination demonstrated a manageable safety profile and encouraging activity