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The ten-year HCC incidence in HC patients with liver cirrhosis is 610%, and is higher in men than in women [46]

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Additionally, in contrast to other drug-loaded LDH systems that typically lose surface charge during modification [26, 40], Se/LDH@PEG-M retained a positive surface charge, which may facilitate enhanced cellular internalization via electrostatic interactions with negatively charged cell membranes [41]

Furthermore, GSH plays an essential role in the glutathione-ascorbate cycle, facilitating the reduction of hydrogen peroxide (HO)a highly reactive oxidant that, if not neutralized, can damage lipids, proteins, and DNA (48)

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38 Among secondary dystonias, DBS has been shown to demonstrate benefit in individuals with medically refractory tardive dystonia