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Move: The next layer is mast-cell-targeted work, gut-axis evaluation, or clinical workup, not a dose-escalated KLOW

Once produced, GSH can undergo conjugation with toxic substances (Noctor et al., 2012

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The rapid disruption of cellular homeostasis leads to the release of various signaling molecules and ions from damaged cells

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The combination of different drugs targeting different signal pathways could prevent or delay the development of resistance mechanisms, often, however, at cost of increased toxicities