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826 Downregulation of Panx1 significantly reduces ferroptosis and iron accumulation in renal cells induced by erastin, through inducing HO-1 expression and the mitogen-activated protein kinase (MAPK)/ERK pathway

In addition, other studies have shown that in the brains of patients with AD, there is an accumulation of 27-OHC and a reduction in 24S-OHC (Leoni et al., 2002

Science 361 , 842844 (2018)

This multi-level, multi-angle evidence chainfrom clinical observation to cell models and animal interventionscollectively supports ferroptosis as a critical link in OA cartilage pathology, with GPX4 dysfunction permeating this process

[DOI] [PubMed] [Google Scholar] 35.Thompson J.S., Thornton A.C., Ainger T., Garvy B.A

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