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Purine compounds are either produced in the body or accumulate from eating high-purine foods

The study involved 411 adult patients with T2DM and was designed as a randomized, double-blind, placebo-controlled trial where patients received varying doses of danuglipron or a placebo

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The dual-mechanism approach may also offer specific advantages for particular patient subgroups, including those with type 2 diabetes and obesity where cardiometabolic improvements beyond weight loss are clinically important

A separate trial linked the same GHRH approach to gains in lean body mass, though its approved use stays narrow

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