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First, PPI-induced hormonal changes, such as hypergastrinemia and hyperparathyroidism, affect intestinal osmolality as well as calcium and phosphorus metabolism, which in turn affect the intestinal flora (Yang and Metz, 2010)

Targeting to NRF2 antioxidant pathway is a novel therapeutic strategy

PMID: 35312863

Molnar A, Csorba T, Lakatos L, Varallyay E, Lacomme C, Burgyan J
Most importantly, boosting NAD metabolism has been shown to extend the lifespan of various organisms, including mice

Ravandi F, Kantarjian H, Thomas D, Faderl S, Jones D, Koller C, Dara S, Garris R, Kebriaei P, Champlin R, Borthakur G , Wierda W, Burger J, Cortes J, O'Brien S
