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Zonation differences are associated with phase I and phase II metabolism enzymes, with a predominant centrilobular localization of most constitutively expressed P450s (Figure 1A and 1B) and other phase I enzymes and a predominant periportal expression of most phase II enzymes

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Am J Physiol Heart Circ Physiol 291: H581H590, 2006 [DOI] [PubMed] [Google Scholar] 28.Canli , Alanku YB, Grootjans S, Vegi N, Hltner L, Hoppe PS, Schroeder T, Vandenabeele P, Bornkamm GW, and Greten FR

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Discard if there are signs of contamination, full discolouration, or moisture damage