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While all three genes have multiple AP-1-binding sites, only GCLC has an NFB-binding site

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For example, monocyte chemoattractant protein-1 recruits immune cells to the injured area for targeted inflammation regulation (Chen et al., 2017a), whereas Interleukin (IL)-6 and IL-8 stimulate proliferative pathways in hepatic cells and promote the recruitment of neutrophils and macrophages, thereby enhancing tissue repair (Qiu et al., 2012

(See figure below showing the methylation and transsulfuration pathways.) Glutathione production starts with the amino acid cysteine

FSP1 can also effectively inhibit ferroptosis through the non-classical vitamin K oxidationreduction cycle

The study also revealed that FSP1 is an efficient reductase that reduces vitamin K to VKH2, driving a novel non-classical vitamin K cycle