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Glutamate acts through eight ionotropic and metabotropic receptor subtypes (mGluR1mGluR8) that have been classified into three groups: Group I receptors (mGluR1 and mGluR5) are coupled to G q proteins and phospholipase C and are involved in central sensitization and pain chronification

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Activation of the other two isoforms, PPAR/ and PPAR, also contributes to the maintenance of carnitine homeostasis [197, 198]

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