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443 Furthermore, systemic AAV vector-mediated LAV-BPIFB4 gene transfer has been shown to redirect circulating SnCs to the spleen and increase the activity of immune cells within the spleen, thereby effectively eliminating senescent immune cells

Association of oxidative balance score with sleep quality: NHANES 2007-2014

The differential metabolite N-acetylglutamate (NAG) activates the KEAP1-NRF2 pathway and concurrently inhibits ferroptosis, thereby mediating a protective effect

Guyton and Hall Textbook of Medical Physiology

The deficiency or mutation of the enzyme has been linked with various disease conditions and abnormalities.39 Zmock and Koller associated oxidative DNA damage and subsequent risk of cancer susceptibility in individuals with genetic polymorphisms and altered gene expression/activity in catalase.40 Development of mental disorder has also resulted from polymorphism in the catalase-encoding gene.41 In addition, humans with low catalase levels (acatalasemia) are said to be more predisposed to type 2 diabetes mellitus (Fig