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10.1038/s41389-017-0011-9 46 PirouzmandM.SaniP

tautomer refers to one of two or more structural isomers which exist in equilibrium and which are readily converted from one isomeric form to another

Iron-driven oxidation of dopamine results in the generation of 6-OHDA, which specifically inhibits mitochondrial complexes I and IV, leading to mitochondrial dysfunction (120)

Most of the antidepressant drugs were metabolized via CYP2D6 enzyme

The core mechanism consists of an inflammatory cascade: the exposure to LPS initiates the release of pro-inflammatory cytokines, including TNF- and IL-1, as well as the production of ROS, which results in a depletion of GSH