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[DOI] [Google Scholar] 7.Di L

Burianov 1 , A

Bernhoft RA (2012) Mercury toxicity and treatment: a review of the literature

reported that in NSCLC patients, combining a PD-1 immune checkpoint inhibitor with erastin enhanced CD8+ T cell-mediated IFN secretion, downregulating SLC7A11 and reversing immune resistance, resulting in an improved objective response rate of 32% in a phase II clinical trial(NCT04205357) (323)

In this model, the reduced anti-tumor immunity of sleep-deprived animals was also indexed by the reduced number of antigen-presenting cells (dendritic cells) in the lymph nodes, as well as by the decreased effector CD4 T-cell numbers and corresponding cytokine profile (decreased IFN-), resulting in lowered Th1 response of Th cells, i.e., the most effective immune response against tumors

2.2.3 Induction of macrophage dysfunction Macrophages are crucial immune myeloid cells involved in both innate and adaptive immune responses (127129)