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38 Further prospective randomised clinical trials (RCTs) will need to be performed prior to the routine recommendation of HA

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-MSH therefore can arise from melanotrophs within the pituitary gland or POMC cleavage in the periphery, and has been shown to have a high affinity with the MC1R receptor in human melanocytes [22, 23]

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doi: 10.1093/toxsci/kfu036 83 RouttiHBergMKLille-LangyRygardenLHarjuMDietzRet al