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Jain A, Martensson J, Stole E, Auld PA, Meister A (1991) Glutathione deficiency leads to mitochondrial damage in brain

Due to its delocalized positive charge, berberine can disrupt mitochondrial membrane potential and upregulate the content of ROS

Glutamine is a precursor of glutamate and is involved in the maintenance of nitrogen balance and the promotion of protein synthesis (66)

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Considering that ALA could effectively stabilize hepatic Fe 2+ expression (Figure 1), and depress both levels of ferroptotic (Figure 2) and pro-apoptotic signaling (Figure 6), dietary supplementation with ALA may thus serve as a useful and practical way to prevent, or further counteract the CSD-induced liver injury and metabolic deficiency