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Polyamines pathway is also related with breast cancer, being elevated and correlating with poor prognosis and cancer cell growth [161,162,163,164]

10.1002/elsc.202100167 28 CavadasM.Gonzlez-Fernndez.FrancoR

Studies specifically in muscle cells have shown that IGF-1 LR3 activates mTOR signaling, increases phosphorylation of p70S6K and 4E-BP1, enhances myotube formation, increases myotube diameter (hypertrophy), and promotes satellite cell activation more effectively than native IGF-1

A subsequent study, which added a placebo arm and had a treatment duration of 12 weeks also obtained similar results, not finding significant differences between the levels of LH, FSH, PRL, 17-hydroxyprogesterone (17-OH), T and E2 between the studied groups (Gonzales et al., 2003)
During the latter, GSH acts as a reducing agent and donates an electron in the presence of the enzyme glutathione peroxidase (GPx), thereby giving rise to its oxidized form, GSSG (Higuchi, 2014)
