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Yu JH, Park SY, Lee DY, Kim NH, Seo JA

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Case reports with a variant exposure time of GLP-1 RA during pregnancy report uneventful pregnancies and births, while animal model organism studies have shown signs of repro-toxicity with a reduction in embryonic survival, growth restriction, and skeletal malformation (Greco, 2015

Such difference may arise from the subtle changes in pocket residues at 3.37b (H268 for GLP-2R, Q234 for GLP-1R and Q232 for GCGR), 3.40b (V271 for GLP-2R, V237 for GLP-1R and I235 for GCGR) and ECL2 (N334 for GLP-2R, R299 for GLP-1R and N298 for GCGR)