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Although the limited ability of paclitaxel to cross the intact bloodbrain barrier initially suggested indirect mechanisms of action, research now indicates that paclitaxel can indeed reach brain tissue, particularly the hippocampus, at concentrations sufficient to induce neurotoxicity (Tang et al., 2022)

[DOI] [PubMed] [Google Scholar] 28.Chang C-H, Tsai W-C, Lin M-S, Hsu Y-H, Pang J-HS

Cur and CDDP were administered at doses of 0.59 and 2 mg/kg, respectively

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Three forms of SOD are known in mammals: cytoplasmic SOD (SOD1), mitochondrial SOD (SOD2), and extracellular SOD (SOD3) (49)