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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders (see Contraindications and Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use as follows)

Depending on their subcellular localization and the existence of unique cis-acting regulatory elements in the upstream promoter region, various GPX genes respond differently to environmental stresses

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Additionally, it investigates the impact of this combination therapy on the biological functions and energy metabolism of glioma cells

Aids in carbohydrate metabolism and energy production

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