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Nearly all compounds showed an excellent selectivity profiles against DASH- (dipeptidyl peptidase-IV activity and/or structure homologues)-enzymes (DPP2, DPP8, DPP9) and non-DASH-enzymes (post-proline cleaving enzyme (PPCE), neutral endopeptidase (NEP), aminopeptidase P (APP) and aminopeptidase N (APN)

2017: The FDA approves a long-acting, once weekly GLP-1 RA injectable exenatide (Bydureon BCise)

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