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Using sdAbs and scaffold proteins as radiopharmaceuticals has shown significant advantages, though bone marrow and kidney toxicity remain concerns

Stockwell B, Pedro J, Friedmann Angeli JP, Bayir H, Bush A, Conrad M, et al

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Further studies and additional models are needed to clarify whether this reflects increased toxicity or immune activation

doi: 10.1016/S0002-9440(10)63698-X 275 PistoriusK.SouzaP
Glu and Gln are compartmentalized in neurons and glia, respectively, and this chemical inter-conversion reflects an important aspect of metabolic interaction between these two types of cells
