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In clinical settings, nootropics have been explored for recovering cognitive function after events like traumatic brain injury or stroke, and for mild cognitive impairment, but such uses remain experimental and part of clinical trials rather than standard care

Effect of monosodium L-glutamate (umami substance) on cognitive function in people with dementia

APOE4-associated deficits in glycolysis were compensated by enhancing the activity of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1), a key regulator of energy metabolism, which might be due to an increase hexokinase 1 (Hk1) expression [93]

Glycation by ascorbic acid oxidation products leads to the aggregation of lens proteins

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Often, yes, but not always