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It was proven that lipophilic antioxidants can inhibit this mode of cell death, which are the main characteristics of ferroptosis (8)
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Studies on CHAC 1 and CHAC 2 have shown that the two isoenzymes both promote the intracellular degradation of GSH, but they appear to act in different contexts
In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38
Botch is a -Glutamyl cyclotransferase that deglycinates and antagonizes notch
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
