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Anti-Inflammatory Activity of Alpha-Lipoic Acid Inflammation is the consequence of an innate biological response to injurious agents

3 Mechanisms of action of natural supplements against breast cancer 3.1 Anti-inflammatory and antioxidant pathways The chronic inflammatory microenvironment in the breast activates nuclear factor-B (NF-B), cyclooxygenase-2 (COX-2), signalling transducers and activators of transcription-3 (STAT3), activator protein-1, and mitogen-activated protein kinase signalling cascades

Ethics declarations Ethics approval and consent to participate All animal experiments were performed following international guidelines and conducted in accordance with the Animal Ethics Committee of Qingdao University (QDU-AEC-2024766)

10.1161/circgen.120.003142 57

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These strategies can be further expanded to evidence-based anti-ageing and rejuvenation interventions with measurable clinical impact
