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Neurotoxic reactive astrocytes induce cell death via saturated lipids

For a nutrient to influence physiology, it must participate in a known biochemical pathway that already exists within human metabolism

Physiologically, FA is constantly generated through cellular metabolism, i.e., histone and DNA demethylation reactions or the one-carbon cycle, but it can also arise from the diet and it is ubiquitously found in the environment 2,3,4,5

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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Buse MG

We speculated that when GCL is induced tremendously, the step catalyzed by GS might become limiting