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There is evidence that the mTOR signaling pathway acts as a key controller of cellular senescence

The intriguing possibility of targeting the IGF axis for treating cardiovascular and metabolic disorders remains uncertain due to adverse effects observed in pre-clinical and clinical studies

Briefly, before use, the precursor of Schaaps 1,2-dioxetane with a phenylborate moiety (compound AGL) needs to be oxidized to form compound 16 by singlet oxygen provided by the AIEgen (TPE-TV-CyP) under white light irradiation

PMID: 28434844

A new Nrf2 inhibitor enhances chemotherapeutic effects in Glioblastoma cells carrying p53 mutations

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